New manuscript published in Cancer Research E-pub ahead of print
Cancer Research 2011 Sep 7.
Quantifying the role of angiogenesis in malignant progression of gliomas:
In silico modeling integrates imaging and histology.
Swanson KR, Rockne RC, Claridge J, Chaplain MA, Alvord EC Jr, Anderson AR.
Although commonly attributed to molecular-genetic factors such as the accumulation of genetic mutation, this study combines mathematical modeling with experimental and clinical data for human gliomas to suggest that changes in cell kinetics are not necessary to generate the imaging and histological features of malignant progression seen in vivo. Model predictions are validated against imaging and histological data for 3 GBM patients.