{"id":2141,"date":"2014-12-10T11:13:00","date_gmt":"2014-12-10T17:13:00","guid":{"rendered":"http:\/\/mathematicalneurooncology.org\/?p=2141"},"modified":"2014-12-10T11:21:39","modified_gmt":"2014-12-10T17:21:39","slug":"the-mathematical-neuro-oncology-research-lab-presents","status":"publish","type":"post","link":"https:\/\/mathematicalneurooncology.org\/?p=2141","title":{"rendered":"MNO Lecture Series: December 11th 2014, Kit Curtius"},"content":{"rendered":"<p><b><span style=\"color: #1f1b47; font-size: large;\"><span style=\"color: #1f1b47; font-size: large;\">The Mathematical Neuro-Oncology Research Lab Presents<\/span><\/span><\/b><br \/>\n<strong><img loading=\"lazy\" class=\"alignleft\" src=\"https:\/\/mathematicalneurooncology.org\/wp-content\/uploads\/2014\/12\/Kit-300x285.png\" alt=\"\" width=\"300\" height=\"285\" \/><\/strong><br \/>\n<strong>Kathleen (Kit) Curtius<\/strong><br \/>\nNSF Research Fellow<br \/>\nDepartment of Applied Mathematics<br \/>\nUniversity of Washington<br \/>\nFred Hutchinson Cancer Research Center<br \/>\n<br clear=all><br \/>\n<strong>How long has that been there?<br \/>\nMulti-scale modeling of Barrett\u2019s Esophagus<\/strong><\/p>\n<p>Thursday, December 11th, 2014<br \/>\n12:00 pm \u2013 1:00 pm<br \/>\nArkes Pavilion,<br \/>\n676 n. Saint Clair St. Suite 1300<br \/>\nMathematical Neuro-Oncology Lab<\/p>\n<p>Although the development of Barrett&#8217;s esophagus (BE) is considered an important first step in the progression to esophageal adenocarcinoma (EAC), BE is asymptomatic &#8211; so the duration of time a patient has harbored BE is generally not known when she\/he is first diagnosed. This is particularly unfortunate because the duration that BE has been present in a patient correlates strongly with the risk of BE transforming into EAC. Recently identified clock-CpGs allow a novel characterization of a tissue in terms of its biological age, and these markers are used to show accelerated tissue aging in a variety of tumors. We seek markers of differential epigenetic drift from genome-wide DNA-methylation array data from BE patients in order to predict BE tissue age. We then estimate individual-level BE onset times and the subsequent risk of progressing to dysplasia and EAC using a mathematical model. This work translates DNA-methylation &#8220;footprints&#8221; of tissue-aging into &#8220;time&#8221; information to estimate important time scales in the step-wise progression to dysplasia and cancer in BE patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Mathematical Neuro-Oncology Research Lab Presents Kathleen (Kit) Curtius NSF Research Fellow Department of Applied Mathematics University of Washington Fred Hutchinson Cancer Research Center How long has that been there? Multi-scale modeling of Barrett\u2019s Esophagus Thursday, December 11th, 2014 12:00 pm \u2013 1:00 pm Arkes Pavilion, 676 n. Saint Clair St. Suite 1300 Mathematical Neuro-Oncology &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/mathematicalneurooncology.org\/?p=2141\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;MNO Lecture Series: December 11th 2014, Kit Curtius&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/2141"}],"collection":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2141"}],"version-history":[{"count":5,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/2141\/revisions"}],"predecessor-version":[{"id":2147,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/2141\/revisions\/2147"}],"wp:attachment":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}