{"id":1726,"date":"2013-04-11T14:27:59","date_gmt":"2013-04-11T19:27:59","guid":{"rendered":"http:\/\/mathematicalneurooncology.org\/?p=1726"},"modified":"2013-09-11T14:29:10","modified_gmt":"2013-09-11T19:29:10","slug":"congratulations-to-ms-baldock-on-her-new-paper-in-frontiers-in-oncology","status":"publish","type":"post","link":"https:\/\/mathematicalneurooncology.org\/?p=1726","title":{"rendered":"Congratulations to Ms. Baldock on her new paper in Frontiers in Oncology"},"content":{"rendered":"<h1>From patient-specific mathematical neuro-oncology to precision medicine<\/h1>\n<div><a href=\"https:\/\/www.frontiersin.org\/Community\/WhosWhoActivity.aspx?sname=AnneBaldock&amp;UID=74210\">A. L. Baldock<\/a><sup>1,2<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/community.frontiersin.org\/people\/RussellRockne\/84767\">R. C. Rockne<\/a><sup>1,2,7<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 A. D. Boone<sup>3<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 M. L. Neal<sup>3,4<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/community.frontiersin.org\/people\/AndreaHawkins-Daarud\/63286\">A. Hawkins-Daarud<\/a><sup>1,2<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/community.frontiersin.org\/people\/DavidCorwin\/84763\">D. M. Corwin<\/a><sup>1,2<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/community.frontiersin.org\/people\/CarlyBridge\/84822\">C. A. Bridge<\/a><sup>1,2<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 L. A. Guyman<sup>1,2<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/community.frontiersin.org\/people\/AndrewTrister\/84831\">A. D. Trister<\/a><sup>5<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 M. M. Mrugala<sup>6<\/sup>,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 J. K. Rockhill<sup>5<\/sup> and <a href=\"https:\/\/community.frontiersin.org\/people\/KristinSwanson\/35107\">K. R. Swanson<\/a><sup>1,2,7<\/sup>*<\/div>\n<ul>\n<li><sup>1<\/sup>Department of Neurological Surgery, Northwestern University, Chicago, IL, USA<\/li>\n<li><sup>2<\/sup>Brain Tumor Institute, Northwestern University, Chicago, IL, USA<\/li>\n<li><sup>3<\/sup>Department of Pathology, University of Washington, Seattle, WA, USA<\/li>\n<li><sup>4<\/sup>Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA, USA<\/li>\n<li><sup>5<\/sup>Department of Radiation Oncology, University of Washington, Seattle, WA, USA<\/li>\n<li><sup>6<\/sup>Department of Neurology, University of Washington, Seattle, WA, USA<\/li>\n<li><sup>7<\/sup>Department of Applied Mathematics, University of Washington, Seattle, WA, USA<\/li>\n<\/ul>\n<p>Gliomas are notoriously aggressive, malignant brain tumors that have variable response to treatment. These patients often have poor prognosis, informed primarily by histopathology. Mathematical neuro-oncology (MNO) is a young and burgeoning field that leverages mathematical models to predict and quantify response to therapies. These mathematical models can form the basis of modern \u201cprecision medicine\u201d approaches to tailor therapy in a patient-specific manner. Patient-specific models (PSMs) can be used to overcome imaging limitations, improve prognostic predictions, stratify patients, and assess treatment response <em>in silico<\/em>. The information gleaned from such models can aid in the construction and efficacy of clinical trials and treatment protocols, accelerating the pace of clinical research in the war on cancer. This review focuses on the growing translation of PSM to clinical neuro-oncology. It will also provide a forward-looking view on a new era of patient-specific MNO.<\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/Journal\/Abstract.aspx?ART_DOI=10.3389\/fonc.2013.00062&amp;name=molecular_and_cellular_oncology\">https:\/\/www.frontiersin.org\/Journal\/Abstract.aspx?ART_DOI=10.3389\/fonc.2013.00062&amp;name=molecular_and_cellular_oncology<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From patient-specific mathematical neuro-oncology to precision medicine A. L. Baldock1,2,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 R. C. Rockne1,2,7,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 A. D. Boone3,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 M. L. Neal3,4,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 A. Hawkins-Daarud1,2,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 D. M. Corwin1,2,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C. A. Bridge1,2,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 L. A. Guyman1,2,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 A. D. Trister5,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 M. M. Mrugala6,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 J. K. Rockhill5 and K. R. Swanson1,2,7* 1Department of Neurological Surgery, Northwestern University, Chicago, IL, USA 2Brain Tumor Institute, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/mathematicalneurooncology.org\/?p=1726\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Congratulations to Ms. Baldock on her new paper in Frontiers in Oncology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/1726"}],"collection":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1726"}],"version-history":[{"count":1,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/1726\/revisions"}],"predecessor-version":[{"id":1727,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/1726\/revisions\/1727"}],"wp:attachment":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1726"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1726"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}