New manuscript published in PLoS ONE (in press).<\/p>\n
Discriminating time to progression and survival using a response metric tuned to patient-specific glioblastoma kinetics<\/strong><\/p>\n Neal ML, Trister AD, Cloke T, Sodt R, Ahn S, Baldock AL, Bridge CA, Boone A, Rockne R, Swanson KR.<\/p>\n Accurate clinical assessment of a patient\u2019s response to treatment for glioblastoma multiforme (GBM), the most malignant type of primary brain tumor, is undermined by the wide patient-to-patient variability in GBM dynamics and responsiveness to therapy. Using computational models that account for the unique geometry and kinetics of individual patients\u2019 tumors, we developed a method for assessing response that discriminates progression-free and overall survival following therapy for GBM. Applying these models as untreated virtual controls, we generate a patient-specific \u201cDays Gained\u201d response metric that estimates the number of days a therapy delayed imageable tumor progression. We assessed treatment response in terms of Days Gained scores for 33 patients at the time of their first MRI scan following first-line radiation therapy. Based on Kaplan-Meier analyses, patients with significant treatment response (characterized by Days Gained scores of 100 or more) had improved progression-free survival and improved overall survival. Our results demonstrate that the Days Gained response metric calculated at the routinely acquired first post-radiation treatment time point provides prognostic information regarding progression and survival outcomes. Applied prospectively, our model-based approach has the potential to improve GBM treatment by accounting for patient-to-patient heterogeneity in GBM dynamics and responses to therapy.<\/p>\n","protected":false},"excerpt":{"rendered":" New manuscript published in PLoS ONE (in press). Discriminating time to progression and survival using a response metric tuned to patient-specific glioblastoma kinetics Neal ML, Trister AD, Cloke T, Sodt R, Ahn S, Baldock AL, Bridge CA, Boone A, Rockne R, Swanson KR. Accurate clinical assessment of a patient\u2019s response to treatment for glioblastoma multiforme … <\/p>\n