{"id":1061,"date":"2011-10-19T21:45:42","date_gmt":"2011-10-19T21:45:42","guid":{"rendered":"http:\/\/depts.washington.edu\/krslab\/?p=1061"},"modified":"2011-10-21T18:46:48","modified_gmt":"2011-10-21T18:46:48","slug":"uvic-grant-award","status":"publish","type":"post","link":"https:\/\/mathematicalneurooncology.org\/?p=1061","title":{"rendered":"NIH R01 &#8220;UVIC&#8221; Grant Award"},"content":{"rendered":"<p style=\"text-align: center;\">Untreated Virtual Imaging Control (<strong>UVIC<\/strong>)<\/p>\n<p style=\"text-align: center;\">funded by the National Institutes of Health (<a title=\"www.nih.gov\" href=\"https:\/\/www.nih.gov\" target=\"_blank\">www.nih.gov<\/a>).<\/p>\n<p>The UVIC grant proposal integrates mathematical modeling of tumor proliferation and invasion with\u00a0advanced cancer imaging methods. The goals of our project are\u00a0twofold:<\/p>\n<p>1) To impact current clinical challenges with treatment of gliomas<\/p>\n<p>2) provide\u00a0tools for the development of new therapies for these challenging cancers.<\/p>\n<p>Our first goal is to develop image-based response metrics based on the growth kinetics\u00a0of each patient\u2019s tumor, as seen on both anatomical imaging (MR) and functional\u00a0imaging (PET and advanced MR). We will use mathematical modeling to develop a\u00a0patient-specific <strong>UVIC<\/strong> that quantifies the dynamics\u00a0of each patient&#8217;s tumor system. We will then test the <strong>UVIC<\/strong> model against a\u00a0<span style=\"text-decoration: underline;\"> novel set of paired PET and MR images at multiple time-points<\/span> (five on average) for each of 20 glioblastoma patients.<\/p>\n<p>The overall goal of this project is to extend the UVIC model to the early response assessment of individual patients in clinical trials. This will provide a tool for\u00a0the development of much-needed therapies that are more effective for gliomas.<\/p>\n<p style=\"text-align: center;\">The core investigators include<\/p>\n<p style=\"text-align: center;\">Kristin Swanson &#8211; University of Washington<\/p>\n<p style=\"text-align: center;\"><a title=\"Paul Kinahan\" href=\"https:\/\/faculty.washington.edu\/kinahan\/\" target=\"_blank\">Paul Kinahan<\/a>\u00a0&#8211; Image Research Lab (IRL) University of Washington<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Untreated Virtual Imaging Control (UVIC) funded by the National Institutes of Health (www.nih.gov). The UVIC grant proposal integrates mathematical modeling of tumor proliferation and invasion with\u00a0advanced cancer imaging methods. The goals of our project are\u00a0twofold: 1) To impact current clinical challenges with treatment of gliomas 2) provide\u00a0tools for the development of new therapies for these &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/mathematicalneurooncology.org\/?p=1061\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;NIH R01 &#8220;UVIC&#8221; Grant Award&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/1061"}],"collection":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1061"}],"version-history":[{"count":6,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/1061\/revisions"}],"predecessor-version":[{"id":1065,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=\/wp\/v2\/posts\/1061\/revisions\/1065"}],"wp:attachment":[{"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mathematicalneurooncology.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}