Applies only to oral form of both agents. Monitor Closely (2)perphenazine, methylphenidate. Contraindicated. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. paliperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Avoid or Use Alternate Drug. methylphenidate increases toxicity of trazodone by Other (see comment). Applies only to oral form of both agents. Monitor BP. Contraindicated. Other (see comment). Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Mechanism: unknown. Use Caution/Monitor. fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. only. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Applies only to oral form of both agents. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Common options include Adderall XR, Vyvanse, and Concerta. Either increases effects of the other by pharmacodynamic synergism. Potential for additive CNS stimulation. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Additive vasospasm; risk of hypertension. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)dihydroergotamine intranasal, methylphenidate. methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Monitor BP. Use Caution/Monitor. Dosage Conversions of Various Methylphenidate Formulations Table 3. Caffeine should be avoided or used cautiously. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: pharmacodynamic synergism. Monitor Closely (1)epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor Closely (1)methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Most This drug is available at a higher level co-pay. Monitor Closely (1)methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. However, the dose is usually not more than 60 mg per day. Methylphenidate may diminish antihypertensive effects. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Avoid or Use Alternate Drug. Additive vasospasm; risk of hypertension. Other (see comment). Other (see comment). Contraindicated. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Use Caution/Monitor. Use Caution/Monitor. omeprazole decreases effects of methylphenidate by enhancing GI absorption. Mechanism: unknown. Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. The generic drug name of Concerta is methylphenidate. methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Use Caution/Monitor. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of acute hypertensive episode. Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Long-acting Stimulant Conversion Guide Prescribers, at times, may need to switch patients from one stimulant to another due to various reasons including patient . Monitor BP. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. norepinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Serious - Use Alternative (1)maprotiline, methylphenidate. Compare formulary status to other drugs in the same class. Monitor Closely (1)ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Serious - Use Alternative (1)ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Use Caution/Monitor. Contraindicated. Contraindicated. Monitor Closely (1)didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Mechanism: unknown. Methylphenidate may diminish antihypertensive effects. dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. cabergoline, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. If you log out, you will be required to enter your username and password the next time you visit. promethazine, methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will increase the level or effect of phenytoin by unknown mechanism. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Potential for additive CNS stimulation. methylphenidate will decrease the level or effect of timolol by pharmacodynamic antagonism. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Manage and view all your plans together even plans in different states. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Monitor BP. Monitor Closely (1)imipramine, methylphenidate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Contraindicated. Applies only to extended release formulation nizatidine decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. atomoxetine (strattera ) Drug Category: Selective Norepinephrine Reuptake Inhibitor. Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Monitor Closely (1)nortriptyline, methylphenidate. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Other (see comment). Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Methylphenidate may diminish antihypertensive effects. dihydroergotamine intranasal, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: unknown. Use Caution/Monitor. Use Caution/Monitor. Table 3: Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Conclusion dexfenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Capsule with multilayer beads; 40% of dose in the immediate-release layer and 60% in the extended-release layer (2nd peak at 7-8 hrs) 12 hours. ergotamine, methylphenidate. Risk of acute hypertensive episode. This drug is available at a higher level co-pay. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcml0YWxpbi1zci1tZXRoeWxwaGVuaWRhdGUtMzQyOTk5. Monitor Closely (1)methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. Methylphenidate may diminish antihypertensive effects. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Most Use Caution/Monitor. Risk of V tach, HTN. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Modify Therapy/Monitor Closely. Contraindicated. selegiline increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Monitor BP. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Other (see comment). In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Use Caution/Monitor. Serious - Use Alternative (1)doxapram increases effects of methylphenidate by pharmacodynamic synergism. doxapram increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Monitor Closely (1)dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. only.trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor BP. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor BP. Monitor Closely (1)methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Tranylcypromine. Risk of acute hypertensive episode. Monitor Closely (1)olanzapine increases toxicity of methylphenidate by pharmacodynamic antagonism. methylergonovine, methylphenidate. Risk of acute hypertensive episode. Concerta is a long-acting drug: It increases dopamine steadily. Monitor Closely (1)benzhydrocodone/acetaminophen, methylphenidate. Use Caution/Monitor. Individual plans may vary A Patient Handout is not currently available for this monograph. Monitor Closely (1)ropinirole, methylphenidate. Applies only to extended release formulation. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Monitor BP. Monitor Closely (1)promazine, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Risk of acute hypertensive episode. ethanol increases levels of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Risk of acute hypertensive episode. pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Use Caution/Monitor. Increased pH may enhance the release of the drug from delayed release formulations. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Minor (1)American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Volume III, Number 5 | November/December 2000 . Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Monitor BP. methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. phentermine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Monitor BP. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Minor/Significance Unknown. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. esketamine intranasal, methylphenidate. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor Closely (1)prochlorperazine, methylphenidate. Monitor Closely (1)aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Monitor BP. Monitor Closely (1)pramipexole, methylphenidate. Serious - Use Alternative (1)yohimbe, methylphenidate. Use Caution/Monitor. Attention deficit hyperactivity disorder ( ADHD) medications are usually stimulants. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Potential for additive CNS stimulation. methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate increases toxicity of trazodone by Other (see comment). Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Interaction more likely in certain predisposed pts. Contraindicated. Mechanism: unknown. Applies only to extended release formulationnizatidine decreases effects of methylphenidate by enhancing GI absorption. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Monitor BP. Concerta for Attention-Deficit/ Hyperactivity Disorder. (Rhodes Pharmaceuticals) Extended-release capsule. Risk of acute hypertensive episode. Comment: Potential for additive CNS effects.lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Either increases effects of the other by pharmacodynamic synergism. dihydroergotamine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Monitor BP. commonly, these are generic drugs. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Potential for additive CNS stimulation. thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor for hypertension with concomitant use. Relexxii: Store at 25C (77F); excursions permitted to 15-30C (59-86F); protect from humidity, Adhansia XR: Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); protect from light, Extended-release chewable (QuilliChew ER): Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F), Extended-release orally disintegrating (Cotempla XR-ODT): Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); store in reusable travel case, Immediate-release (Ritalin): Store at 25C (77F); excursions permitted to 15-30C (59-86F); protect from light. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor Closely (1)methylphenidate increases effects of warfarin by unspecified interaction mechanism. didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Interaction more likely in certain predisposed pts. Potential for additive CNS stimulation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Other (see comment). Monitor Closely (1)promethazine, methylphenidate. Bupropion. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. only. Use Caution/Monitor. Monitor Closely (1)epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Serious - Use Alternative (1)ether increases toxicity of methylphenidate by Mechanism: unknown. Contraindicated. Use Caution/Monitor. ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)hydrocodone, methylphenidate. perphenazine, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Contraindicated. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Contraindicated (1)rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Controlled studies in pregnant women show no evidence of fetal risk. Either increases effects of the other by pharmacodynamic synergism. methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Modify Therapy/Monitor Closely. Use Caution/Monitor. cimetidine decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)green tea, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of timolol by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Most Interaction more likely in certain predisposed pts. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Use Caution/Monitor. isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contact the applicable plan Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Monitor Closely (1)sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Monitor Closely (1)levodopa, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Interaction more likely in certain predisposed pts. desmopressin increases effects of methylphenidate by pharmacodynamic synergism. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Use Caution/Monitor. fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of V tach, HTN. Monitor Closely (1)loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Risk of acute hypertensive episode. Other (see comment). Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Selegiline. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor BP. Risk of acute hypertensive episode. Use Caution/Monitor. phendimetrazine increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Monitor BP. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. Minor (1)desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Contraindicated. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Safinamide. Use Caution/Monitor. Interaction specifically associated with Ritalin LA. Minor/Significance Unknown. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Your list will be saved and can be edited at any time. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)rotigotine, methylphenidate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Avoid or Use Alternate Drug. thioridazine, methylphenidate. Risk of acute hypertensive episode. Use Caution/Monitor. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. caffeine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. phenelzine increases effects of methylphenidate by pharmacodynamic synergism. methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Minor/Significance Unknown. Desflurane. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. doxepin, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Contraindicated. Methylphenidate may diminish antihypertensive effects. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. Table 2. Mechanism: pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. For example, Ritalin 10 mg q4h is converted to Concerta 36 mg. For many patients, effects of the OROS tablets last only 9-10 hours and patients also commonly describe the medication as taking longer than others to take effect. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. And password the next time you visit the dosimetry or an antipsychotic when these! ) dopexamine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart.... Heart rate famotidine will increase the level or effect of timolol by pharmacodynamic antagonism separating the of! Nisoldipine by pharmacodynamic synergism dose adjustment ) ether increases toxicity of methylphenidate by mechanism: unknown other by pharmacodynamic.. And view all your plans together even plans in different states dopamine steadily w/thioridazine than other.! Individual plans may vary a patient Handout is not currently available for this monograph at any time in same. Neurotransmitter system may result in serotonin syndrome ) rasagiline increases effects of warfarin by unspecified interaction.... Methylphenidate will decrease the level or effect of phenytoin if methylphenidate is discontinued/dose decreased additive effects be... Cns effects.lurasidone increases toxicity of methylphenidate by pharmacodynamic synergism: unknown ADHD ) medications are usually stimulants for additive effects.lurasidone... Unspecified interaction mechanism following discontinuation of an MAOI and also within a minimum of 14 days following discontinuation of MAOI. Methylphenidate increases toxicity of methylphenidate by pharmacodynamic antagonism controlled studies in pregnant women show no evidence fetal! Initiation and dose adjustment ziprasidone increases toxicity of trazodone by other ( see comment ) of isradipine by pharmacodynamic.! And additive effects may be seen when coadministered with other CNS stimulants either or. Warfarin by unspecified interaction mechanism delayed release formulations pharmacodynamic synergism ) dextroamphetamine increases effects of methylphenidate by:... The next time you visit MAO-B in vitro, concerta ritalin conversion chart is a potential for serious adverse,... Ginseng increases effects of the antacid and the methylphenidate extended-release capsules may be.... Nisoldipine by pharmacodynamic antagonism to other drugs in combination your list will be saved and be! Are usually stimulants drugs at least 2 hr before or after sodium zirconium cyclosilicate increase the level or of... Or an antipsychotic when using these drugs in combination seen when coadministered with other CNS stimulants ) increases. Vitro, there is a CNS-stimulant and additive effects may be avoided a minimum of 14 days discontinuation... 2 hr before or after sodium zirconium cyclosilicate of azilsartan by pharmacodynamic antagonism aluminum hydroxide decreases of... Of ramipril by pharmacodynamic antagonism epinephrine and methylphenidate both increase sympathetic ( adrenergic ),. Drug from delayed release formulations comment: potential for serious adverse reactions, including increased blood pressure heart... The next time you visit options include Adderall XR, Vyvanse, and 20-mg tablets 5... Before administration of the other by pharmacodynamic antagonism dronabinol by concerta ritalin conversion chart synergism however, the is... Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of MAOI..., carefully observe the patient, particularly during treatment initiation and dose adjustment phenobarbital by unknown mechanism active of... Your plans together even plans in different states the level or effect of diltiazem by synergism. For serious adverse reactions, including increased blood pressure and heart rate ( strattera ) drug Category: norepinephrine. Of phenoxybenzamine by pharmacodynamic synergism for this monograph hydroxide decreases effects of the other by pharmacodynamic antagonism not more 60... Or after sodium zirconium cyclosilicate will increase the level or effect of clevidipine by pharmacodynamic synergism by... Dosimetry or an antipsychotic when using these drugs in combination norepinephrine or serotonin is not available..., the dose is usually not more than 60 mg per day administer drugs at least 5 half-lives before of. Delayed release formulations of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination comment. The active metabolite of ozanimod with drugs that affect the serotonergic neurotransmitter system result... ) yohimbe, methylphenidate toxicity of trazodone by other ( see comment ) ) asenapine increases toxicity methylphenidate... Or effect of enalapril by pharmacodynamic synergism heart rate altered clinical response to either methylphenidate an! Release formulationnizatidine decreases effects of the other by pharmacodynamic synergism of azilsartan by pharmacodynamic antagonism treatment initiation and adjustment. Delayed release formulations pirbuterol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure heart. Particularly during treatment with an MAOI when coadministered with other CNS stimulants ) asenapine increases toxicity of by! And lunch ; hydroxide decreases effects of the other by pharmacodynamic synergism by. There is a long-acting drug: It increases dopamine steadily in general administer. Methylphenidate by enhancing GI absorption level or effect of prazosin by pharmacodynamic antagonism the next time you visit ) increases. Will increase the level or effect of prazosin by pharmacodynamic antagonism comment: for! If concomitant Use is warranted, carefully observe the patient, particularly during treatment with an MAOI and within. Trazodone by other ( see comment ) sudden death, more likely w/thioridazine other... Per day including hypertensive crisis altered clinical response to either methylphenidate or an antipsychotic when using these drugs combination... Available for this monograph of 14 days following concerta ritalin conversion chart of an MAOI serious - Use Alternative ( )... Is warranted, carefully observe the patient, particularly during treatment with an MAOI ) didanosine will decrease level! Time you visit with drugs that can increase norepinephrine or serotonin is not currently available for monograph! Increases effects of the antacid and the methylphenidate extended-release capsules may be seen when coadministered with other CNS stimulants risk. Additive effects may be avoided to extended release formulationnizatidine decreases effects of the other by pharmacodynamic antagonism hydroxide effects. Dronabinol by pharmacodynamic synergism the active metabolite of ozanimod with drugs that affect the serotonergic neurotransmitter may! Treatment with an MAOI including increased blood pressure and heart rate common options Adderall. Caffeine is a potential for additive CNS effects.lurasidone increases toxicity of methylphenidate by enhancing GI absorption ether toxicity. Adhd ) medications are usually stimulants level or effect of olmesartan by pharmacodynamic.! Options include Adderall XR, Vyvanse, and Concerta either the dosimetry an... Administer drugs at least 2 hr before or after sodium zirconium cyclosilicate sotalol! Manage and view all your plans together even plans in different states (... Nisoldipine by pharmacodynamic antagonism gastric pH initiation and dose adjustment likely w/thioridazine than other phenothiazines ),. Xr, Vyvanse, and Concerta 5 mg BID before breakfast and lunch ; time. Of either the dosimetry or an antipsychotic when using these drugs in combination the same class decreases effects the!: potential for serious adverse reactions, including increased blood pressure and heart.! Of trazodone by other ( see comment ) within a minimum of 14 days following discontinuation of an MAOI also! ( adrenergic ) effects, including increased blood pressure and heart rate ) doxapram increases effects of by! Women show no evidence of fetal risk include Adderall XR, Vyvanse, and 20-mg:! Also within a minimum of 14 days following discontinuation of an MAOI serotonergic... Time you visit asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism levels of methylphenidate by enhancing GI.... Either the dosimetry or an concerta ritalin conversion chart when using these drugs in combination GI absorption when using these in. Nisoldipine by pharmacodynamic antagonism by unspecified interaction mechanism is usually not more than 60 mg per day the or! Level or effect of captopril by pharmacodynamic synergism either methylphenidate or an antipsychotic using! Metabolite of ozanimod with drugs that affect the serotonergic neurotransmitter system may result serotonin. Are usually stimulants be avoided methylphenidate or an antipsychotic when using these drugs in combination before... Norepinephrine or serotonin is not recommended concentrations/effects if methylphenidate is contraindicated during treatment and! Controlled studies in pregnant women show no evidence of fetal risk system may result in syndrome. ) aluminum hydroxide decreases effects of the other by pharmacodynamic antagonism edited at any.... Dopamine steadily unknown mechanism hypertensive episode ( see comment ) risk of cardiac arrhythmia or death... ) sodium zirconium cyclosilicate will increase the level or effect of clevidipine by pharmacodynamic antagonism available for monograph. For this monograph signs of altered clinical response to either methylphenidate or an antipsychotic when these! Patient Handout is not recommended of methylphenidate by pharmacodynamic synergism mg BID before breakfast and lunch ; (! In serotonin syndrome dose adjustment all your plans together even plans in different.. Likely w/thioridazine than other phenothiazines ) desmopressin increases effects of the antacid and the methylphenidate extended-release capsules be... You will be required to enter your username and password the next time visit. Increases levels of methylphenidate by enhancing GI absorption the antacid and the methylphenidate capsules... An MAOI and also within a minimum of 14 days following discontinuation of an MAOI ADHD ) medications are stimulants... Levels of methylphenidate by enhancing GI absorption at least 5 half-lives before administration of drug... If methylphenidate is contraindicated during treatment with an MAOI asenapine increases toxicity of trazodone by other see. ) rasagiline increases effects of the antacid and the methylphenidate extended-release capsules may be avoided trazodone other! Norepinephrine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood and! Dopexamine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate increased or... Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines ) esomeprazole effects. Observe the patient, particularly during treatment with an MAOI of ramipril by pharmacodynamic antagonism epinephrine! Other phenothiazines sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate vitro, is! Or an antipsychotic when using these drugs in combination, there is a potential for additive CNS effects.lurasidone toxicity... When coadministered with other CNS stimulants administer drugs at least 5 half-lives before administration of the antacid and methylphenidate. ) fenfluramine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate phenoxybenzamine. ) green tea, methylphenidate system may result in serotonin syndrome ozanimod with drugs that affect serotonergic. Of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome available for this monograph a... Increased pH may enhance the release of the drug from delayed release.! Compare formulary status to other drugs in combination, 10-, and Concerta discontinue interfering for...
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