Members: Susan Massey


Susan Massey, Research Scientist

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PhD Applied Mathematics, Univ. of Washington (2016)

MSc Applied Mathematics, Univ. of Washington (2011)

BS Mathematics, Univ. of Washington (2008)

 

 

 

 

  • 2010 National Science Foundation Graduate Research Fellow
  • 2009 VIGRE Award Recipient
  • 2008 SIAM UW Poster Contest Winner!
  • 2007-2008 Boeing Scholar Research Award Recipient
  • 2007 AMGEN Scholar
  • 2006-2008 McNair Scholar

I have been working with Dr. Kristin Swanson since 2007, when I joined the lab as an Amgen scholar. At the time, I was undergraduate student studying Mathematics and taking pre-medicine courses at the University of Washington. This was my first introduction to mathematical biology and tumor modeling—prior to this, I was on track to attend medical school and pursue pediatric neurology. As I became more involved in the work of the lab, however, I became very passionate about using mathematical tools to improve clinical outcomes, and I am now currently finishing my Ph. D. in Applied Mathematics at the University of Washington while working at the Mayo Clinic in Phoenix, Arizona. My research is primarily focused around an ongoing collaboration with Dr. Peter Canoll, Professor of Neuropathology, at Columbia University in New York. Using data from his experimental rat tumors, I am studying the effects of paracrine plateletderived growth factor (PDGF) signaling on the development and progression of gliomas. Through mathematical modeling we have found, for example, that increased PDGF signal in these experimental tumors leads to faster growth, but with a less diffuse invasion profile (Massey SC, et. al., 2012). Both traits have been correlated with aggressiveness of disease in human patients (Harpold H, et. al., 2007). We have also analyzed in situ cell movement patterns in response to various anti-invasive agents in collaboration with Drs. Peter Canoll and Steven Rosenfeld (formerly of Columbia U, now at Cleveland Clinic), the results of which have been published (Ivkovic S, et. al. 2012). I am now looking to better understand how various treatments affect PDGF-driven tumors. In addition to building new mathematical models, I employ various techniques including Latin hypercube sampling (LHS) with partial rank correlation coefficients (PRCC), nondimensionalization, and linear stability analysis to analyze models’ robustness and parameter sensitivity. To solve my model equations, I use an assortment of numerical methods, including fractional step methods paired with a variety of finite difference schemes.

 

Publications

Book Chapters:

G. Chakraborty, R. Sodt, S. Massey, S. Gu, R. Rockne, E.C. Alvord, Jr., and K.R. Swanson: Bridging from Multiscale Modeling to Practical Clinical Applications in the Study of Human Gliomas. In: Multiscale Cancer Modeling. Editors: T.S. Deisboeck, Massachusetts General Hospital and Harvard Medical School, Boston, USA, G. Stamatakos, Institute of Communication and Computer Systems, National Technical University of Athens, Greece. 2010 ISBN 9781439814406

S. C. Massey and K. Swanson: “Reaction-Diffusion Model of PDGF-driven Recruitment in Experimental Glioblastoma.” BioRxiv doi: http://dx.doi.org/10.1101/038471 – to appear in the forthcoming National Cancer Institute (NCI) ‘Handbook of Mathematical Methods in Cancer Biology.’

Papers:

Susan Christine Massey, B.S., Marcela C. Assanah, Ph.D., Kim A. Lopez, M.D., Peter Canoll, M.D., Ph.D., Kristin R. Swanson, Ph.D. Progenitor cell recruitment drives aggressive glioma growth: mathematical and experimental modeling. [Published online ahead of print 7 Feb 2012.] Journal of the Royal Society Interface, 2012. PDF Accessed 8 February 2012. doi: 10.1098/rsif.2012.0030

Ivkovic S, Beadle C, Noticewala S, Massey SC, Swanson KR, Toro LN, Bresnick AR, Canoll P, Rosenfeld SS. Direct Inhibition of Myosin II Effectively Blocks Glioma Invasion In the Present of Multiple Motogens. [Published online ahead of print 4 Jan 2012.] Molecular Biology of the Cell, 2012. http://www.molbiolcell.org/content/early/2012/01/03/mbc.E11-01-0039.long Accessed 8 February 2012.

Elizabeth A. Stoll, Behnum A. Habibi, Andrei M. Mikheev, Jurate Lasiene, Susan Christine Massey, Kristin R. Swanson, Robert C. Rostomily, Philip J. Horner. A subpopulation of neural stem/progenitor cells in the aged subventricular zone has increased mitotic activity. Stem Cells, 29(12):2005-17, 2011.

Susan C. Massey, B.S. Parameter sensitivity investigation of a mathematical model of glioma tumorigenesis mediated by platelet-derived growth factor. The McNair Scholars Journal of the University of Washington, 8:173-185, 2009.

Lee SJ, Seaborn T, Mao FJ, Massey SC, Luu NQ, Schubert MA, Chien JW, Carpenter PA, Moravec C, Martin PJ, Flowers MED. Frequency of abnormal findings detected by comprehensive evaluation at one year after allogeneic hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation, 15(4):416-20, 2009.

Abstracts:

Susan Christine Massey, Kristin R. Swanson, Peter Canoll. Abstracts from the 15th Annual Meeting of the Society for Neuro-Oncology (SNO), November 18–21, 2010, Montreal, Quebec, Canada: “CB-84. PDGF-driven glioma model reveals that environmentally targeted therapies may be more effective at altering recurrent disease kinetics.” Neuro-Oncology, 12(suppl 4): iv25, 2010.

Susan Christine Massey, Peter D. Canoll, Kristin R. Swanson. Abstracts from the 2009 Joint Meeting of the Society for Neuro-Oncology (SNO) and the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Section on Tumors: “45. Modeling the effects of progenitor cell recruitment on glioma growth and progression.” Neuro-Oncology, 11(5): #, 2009.

Dissertation:

Susan Christine Massey “Multi-scale modeling of paracrine PDGF-driven glioma growth and invasion,” PhD Dissertation, University of Washington, 2017. Neuro-Oncology, 12(suppl 4): iv25, 2010.

Conference Presentations

Talks:

“Analyzing in situ cellular motion in experimental animal glioma models.” European Conference for Mathematical and Theoretical Biology, University of Nottingham, Nottinham, UK, July 2016.

“Parameter Sensitivity Investigation of a Mathematical Model of Glioma Angiogenesis via Latin Hypercube Sampling.” European Conference for Mathematical and Theoretical Biology, Jagiellonian University, Kraków, Poland, July 2011.

“Parameter Sensitivity Investigation of a Mathematical Model of Glioma Angiogenesis via Latin Hypercube Sampling.” The Casablanca International Workshop in Mathematical Biology: Analysis and Control, Hassan II University, Casablanca, Morocco, June 2011.

“Paracrine PDGF Signaling and Progression in Experimental Gliomas.” Society for Mathematical Biology (SMB) Annual Meeting 2009 at the University of British Columbia, Vancouver, BC, Canada, July 2009.

“Parameter sensitivity investigation of a mathematical model of glioma tumorigenesis mediated by platelet-derived growth factor.” Mathematical Biosciences Institute (MBI) Workshop 4: Cancer Development, Angiogenesis, Progression, and Invasion at Ohio State University, Columbus, OH, January 2009.

“Parameter sensitivity investigation of a mathematical model of glioma tumorigenesis mediated by platelet-derived growth factor.” Society for Mathematical Biology (SMB) Annual Meeting 2008 at the University of Toronto, Toronto, ON, Canada, July 2008.

“Modeling Glioma Tumorigenesis Mediated by Platelet Derived Growth Factor.” McNair Research Conference, University of Washington, Seattle, WA, May 2008.

 

Posters:

“Parameter sensitivity investigation of a mathematical model of glioma angiogenesis via Latin hypercube sampling.” Presented at the Second Annual Physical Sciences – Oncology Centers (PS-OCs) Network Investigators’ Meeting, San Diego, CA, April 2011.

“PDGF-driven glioma model reveals that environmentally targeted therapies may be more effective at altering recurrent disease kinetics.” Presented at the 2010 Annual Meeting of the Society for Neuro-Oncology, Montreal, QC, Canada, November 2010.

“Modeling the effects of progenitor cell recruitment on glioma growth and progression.” Presented at the 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors, New Orleans, LA, October 2009.

“Parameter sensitivity investigation of a mathematical model of glioma tumorigenesis mediated by platelet-derived growth factor.” Presented at the 2008 SIAM Annual Meeting in San Diego, CA, July 2008.

Related Professional Activities:

Co-organized a mini symposium, “Mathematical Oncology: Impacting the Clinic,” for the 2016 Joint Society for Mathematical Biology Annual Meeting and the European Conference for Mathematical and Theoretical Biology, University of Nottingham, Nottingham, UK. Speakers: David Dingli: “Dynamics of oncolytic virus spread within tumors.” Eunjung Kim: “Phase I trials in melanoma: a framework to translate preclinical findings to the clinic.” Alicia Martínez-González: “Protracted metronomic therapies to target low-grade gliomas malignant transformation.” Jan Poleszczuk: “Proliferation saturation index predicts OPX GTV reduction to prospectively identify patients for adaptive radiotherapy.”

Membership in Professional Organizations:

Society for Mathematical Biology (SMB) – member from May 2008 to present American Mathematical Society (AMS) – member from Jan. 2011 to present Association for Women in Mathematics (AWM) – member from Jan. 2011 to present

Society for Industrial and Applied Mathematics (SIAM) – member from Jan. 2011 to present

 


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